Scientific Committee Chairs
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James Lockey MD, MS
Professor, Department of Environmental Health, Division of Occupational and Environmental Medicine and Pulmonary Division, Department of Internal Medicine, University of Cincinnati College of Medicine
Dr. Lockey is currently principal or co-principal investigator of numerous research studies including a respiratory morbidity and mortality study of workers exposed to refractory ceramic fiber; a study investigating the relationship of diesel exhaust exposure and the risk in young children for developing allergic rhinitis and asthma; a follow up study of workers exposed to asbestiform contaminated vermiculite ore; and the development of environmental sensors for personal exposure assessment of PM1.0 in collaboration with Mechanical, Industrial and Nuclear Engineering at the University of Cincinnati.
Dr. Lockey received presidential appointment to the National Advisory Board on Radiation and Worker Health, and is a member of the UAW-GM Occupational Health Advisory Board. He is a member of the Center for Asbestos Related Diseases, a scientific advisory board involved in investigating the community effects of asbestiform fiber exposure in Libby, Montana.
Andrew Comai MS
Worker and Consumer Exposure, Section Co-Chair
UAW International Representative, Staff Industrial Hygienist, International Union, UAW, Health & Safety Department
Andrew Comai has worked for the UAW International Union Health and Safety Department for 15 years. He conducts plant inspections, fatality investigations and health and safety training programs. He has provided collective bargaining assistance for a number of industry sectors. He is a member of the UAW-GM National Joint Committee for Health and Safety (UAW-GM NJC). He has served as an expert witness on ergonomic injuries before the OSHRC. During his tenure as the Chairman of the Michigan OSHA Health Standards Commission work was completed on an ergonomic standard and an isocyanate standard.
Comai received a Masters of Science degree in industrial hygiene from the University of Michigan School of Public Health, Department of Environmental Health Sciences in 1995.
Gary L. Ellison PhD, MPH
Human Cancer Risk, Section Chair
Epidemiologist/Program Director, Modifiable Risk Factors Branch, Epidemiology and Genomics Research Program (EGRP), Division of Cancer Control and Population Sciences, National Cancer Institute
Gary L. Ellison is an Epidemiologist and Program Director in the Modifiable Risk Factors Branch (MRFB) at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH). MRFB focuses on factors to reduce cancer risk in humans, including exposures to nutritional components; physical activity and energy balance; alcohol and tobacco; and infectious, physical, and chemical agents. Dr. Ellison plans, develops, and directs a research portfolio of grants that focuses on environmental and occupational exposures, including physical and chemical agents, and the etiology of cancer.
Before joining NCI in September 2008, Dr. Ellison was an instructor in the Department of Family and Community Medicine and Research Coordinator for the Computer-Assisted Telephone Interviewing Research Laboratory at the University of Maryland School of Medicine. There, he conducted research in cancer disparities, was a member of the Cancer Research Core in the Office of Policy and Planning, and was Principal Investigator of a population-based pilot study of area-level social and economic composition and modifiable cancer risk factors.
Pertti (Bert) J. Hakkinen PhD
Toxicology/Animal Models /Biomarkers, Section Chair
Acting Head, Office of Clinical Toxicology, and Senior Toxicologist, and Toxicology and Environmental Health Science Advisor (to the Director), Specialized Information Services, National Library of Medicine, National Institutes of Health; Adjunct Associate Professor in Biomedical Informatics Uniformed Services University of the Health Sciences (USUHS)
Dr. Hakkinen is the Senior Toxicologist and Toxicology and Environmental Health Science Advisor in the Division of Specialized Information Services, National Library of Medicine (NLM), (U.S.) National Institutes of Health (NIH). He provides leadership on the development of new resources in toxicology, exposure science, risk assessment and enhancements to existing NLM resources in these fields.
Dr. Hakkinen is the project leader for the Chemical Hazards Emergency Medical Management (CHEMM) tools, represents NLM on various committees, and provides leadership for NLM's participation in national and international efforts in toxicology-, exposure-, and risk assessment-related information. He is an Adjunct Associate Professor in Biomedical Informatics and the co-director of a public health informatics course offered since 2009 at the Uniformed Services University of the Health Sciences (USUHS) in Bethesda, Maryland. Further, he was the Vice-chair of the Scientific Advisory Panel for the Mickey Leland National Urban Air Toxics Research Center (NUATRC) in Houston, Texas from 2003 until the NUATRC closed in 2011.
Philip Harber MD, MPH
Occupational Health Surveillance/Management, Section Co-Chair
Professor of Public Health, University of Arizona College of Public Health; Professor Emeritus, David Geffen School of Medicine, University of California in Los Angeles
Dr. Phil Harber is Professor of Public Health at the University of Arizona College of Public Health. He is also professor emeritus at David Geffen School of Medicine at UCLA, where he has served as chief of the Division of Occupational and Environmental Medicine.
Dr. Harber has served in national roles such as chair of the CDC/NIOSH IRG (Study Section) and vice chair of the RRC for preventive medicine of the Accreditation Council for Graduate Medical Education. He has published over scientific 300 articles, chapters, and abstracts. His major research interests are occupational lung disease, workplace physiology, computer applications, and occupational health delivery systems analysis.
John Holland MD, MPH
Occupational Health Surveillance/Management, Section Co-Chair
Occupational Medicine Consultant
Clinical Professor, Department of Occupational and Environmental Health Sciences, University of Washington
Dr. Holland is a principal in Holland Associates in Seattle, Washington, where he has a consulting practice in occupational and environmental medicine and health services research.
Dr. Holland has spent over 30 years in the full-time practice of occupational and environmental medicine, including extensive experience in clinical care, program administration and applied research activities. He has conducted research, lectured and published on a broad range of topics including evidence-based medicine, clinical practice guidelines, health economics, health and productivity management, clinical care of low back problems, asbestos-related disease and toxicology.
Andrea Pfahles-Hutchens MS
Worker and Consumer Exposure, Section Co-Chair
Epidemiologist, Risk Assessment Division, Office of Chemical Safety and Pollution Prevention (OCSPP), US Environmental Protection Agency
Andrea Pfahles-Hutchens, M.S., is an Epidemiologist in the Risk Assessment Division of the Office of Chemical Safety and Pollution Prevention (OCSPP), U.S. Environmental Protection Agency in Washington, DC. She has been employed by EPA for over 16 years. Andrea provides ongoing technical support for regulatory actions on issues related to epidemiology on many diverse chemicals, including diisocyanates, perfluorochemicals, lead, formaldehyde, polybrominated diphenyl ethers, phthalates, and many others. She has participated for 3 years on EPA’s Spray Polyurethane Foam Workgroup, which, in conjunction with OSHA, NIOSH, CPSC, and ATSDR, has challenged the polyurethane industry to develop health and safety best practices and to identify research needs pertaining to exposures to diisocyanates.
Dr. is also a member of EPA’s MDI and TDI Workgroup developed to implement Action Plans on diisocyanates. Andrea has also served as expert on biomonitoring/biomarker issues for EPA for over 8 years. Andrea has coordinated and directed epidemiologic review of research on perfluorinated chemicals for over 12 years. She also served as Acting Branch Chief of the New Chemicals Screening and Assessment Branch where she implemented many process improvements in the toxicity reviews of Premanufacture Notices. Andrea holds a bachelor’s degree from The Pennsylvania State University and received her Master’s degree in Epidemiology from the University of Cincinnati.
Carrie Redlich MD, MPH
Respiratory Epidemiology and Disease, Section Co-Chair
Professor of Medicine, Professor of Medicine (Occupational Medicine), Director, Occupational and Environmental Medicine Program, Yale University
Carrie A. Redlich, MD, MPH is Director of the Yale Occupational and Environmental Medicine (OEM) Program and Professor of Medicine at Yale University School of Medicine. She is a board certified physician in Occupational and Environmental Medicine, Internal Medicine and Pulmonary Diseases.
Dr. Redlich has been investigating isocyanate exposures, pathogenic mechanisms and health effects for a number of years, integrating animal, clinical and epidemiology approaches, with the assistance of a multidisciplinary group of investigators at Yale, NIOSH and UMass.
Current on-going research projects are focused on assessing and preventing exposures to MDI, now the dominant commercial isocyanate, in factory workers and in the construction industry. Interrelated studies to develop improved isocyanate exposure biomarkers are in progress.
Robert P. Streicher PhD
Environmental Exposure/Monitoring, Section Chair
Chief, Chemical Exposure and Monitoring Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention
Dr. Robert Streicher earned his Ph.D. in Organic Chemistry from the University of Cincinnati in 1987. Immediately upon graduation he joined the National Institute for Occupational Safety and Health (NIOSH) as a Research Chemist in the Methods Research Branch of the Division of Physical Sciences and Engineering. Dr. Streicher's research activities focused on the sampling and analysis of mono- and polyisocyanates in air. In 1998, Dr. Streicher became a Section Chief in the Methods Research Branch and in 2007 was promoted to his current position as Chief of the Chemical Exposure and Monitoring Branch (CEMB) of the Division of Applied Research and Technology.
CEMB conducts sampling and analytical method development research for organic and inorganic substances, develops and evaluates direct-reading monitors, and conducts research to characterize aerosol exposures, such as carbonaceous nanomaterials. A primary product is the NIOSH Manual of Analytical Methods (NMAM). CEMB evaluates methods for inclusion in the NMAM and a majority of CEMB methods are published in the NMAM.
Mark J. Utell MD
Respiratory Epidemiology and Disease, Section Co-Chair
Professor of Medicine and Environmental Medicine, Director, Occupational and Environmental Medicine, University of Rochester Medical Center
Marc Utell is Professor of Medicine and Environmental Medicine, Director of Occupational and Environmental Medicine and former Director of Pulmonary and Critical Care Medicine at the University of Rochester Medical Center. He serves as Associate Chairman of the Department of Environmental Medicine.
His research interests have centered on the effects of environmental toxicants on the human respiratory tract. Dr. Utell has published extensively on the health effects of inhaled gases, particles and fibers in the workplace, indoor and outdoor environments. He is the co-principal investigator of an EPA Particulate Matter Center. He has served as Chair of the Health Effects Institute’s Research Committee, Chair of EPA’s Environmental Health Committee and as a member of the Executive Committee of the EPA Science Advisory Board. He is a former recipient of the NIEHS Academic Award in Environmental and Occupational Medicine.
Scientific Committee Members
Simon Aubin MSc, CIH
Scientific Professional, Laboratory Division. IRSST
Mr. Aubin is a chemist and an industrial hygienist (CIH) in the Laboratory Division of the Institut de recherche en santé et en sécurité du travail (IRSST), Montréal, Canada.
Mr. Aubin completed his Masters degree in analytical chemistry at McGill University (Montréal, Canada) in 2000. He has worked on different air sampling and analysis projects involving the provincial public health division and the Canadian National Defense. In 2001, he joined Biolab, a laboratory specialized in environmental analyses where he was the supervisor of the chemical analysis sector. In 2004, he joined IRSST as the chemist in charge of volatile organic compounds and gravimetric analyses in the Laboratory Division, an industrial hygiene laboratory providing a full analytical service for the provincial health and safety network of the Province of Quebec. Mr. Aubin has been involved in isocyanates sampling and analysis since 2005. He is also a co-author in occupational hygiene research projects involving field and laboratory work.
Karl Auerbach MD, MBA
Managing Scientist, Exponent
Dr. Auerbach brings to Exponent a dual background in biomedical engineering and medicine, providing a unique perspective and cross-disciplinary approach to his work. He is board certified in occupational medicine by the American Board of Preventive Medicine, and is a trained biomedical engineer who uses that knowledge in his approach to his medical activity. He specializes in the biomechanics and dynamics of traumatic injury including vehicle collisions, industrial injuries, and skiing accidents.
Dr. Auerbach’s experience includes treating a broad variety of traumatic and chemical occupational injuries and exposures. He has provided hands-on care of occupational and environmental injuries, and has served as director of a hospital-based practice for many years. He has practiced in emergency rooms as an attending physician for almost 35 years, caring for a broad spectrum of injuries, including automobile accidents and other traumas. He continues that practice.
Dr. Auerbach is also residency trained in internal medicine. He has directed occupational medicine programs and served as a staff physician and Associate Professor of Environmental Medicine at the University of Rochester and also served there as an active attending physician and Associate Professor in the Department of Emergency Medicine. He continues in active practice of occupational and emergency medicine.
John R Balmes MD
Professor of Medicine, School of Medicine, University of California, San Francisco
Dr. Balmes is a Professor of Medicine at the University of California, San Francisco (UCSF) where he is the Chief of the Division of Occupational and Environmental Medicine at San Francisco General Hospital (SFGH), Director of the Human Exposure Laboratory of the Lung Biology Center and Attending Physician in Pulmonary and Critical Care Medicine at SFGH. He is also Professor of Environmental Health Sciences in the School of Public Health at the University of California, Berkeley where he is the Director of the Northern California Center for Occupational and Environmental Health.
In December 2007, he was appointed by Governor Schwarzenegger to be the physician member of the California Air Resources Board. Dr. Balmes has been conducting research on the respiratory and cardiovascular effects of occupational agents and air pollutants for over 25 years.
Xaver Baur MD
Professor for Occupational and Environmental Medicine, Chair of Occupational Health Department of the University Medical Center Hamburg-Eppendorf,
Director of the Institute for Occupational and Maritime Medicine
Xaver Baur is Professor for Occupational and Environmental Medicine, Chair of the Department of Occupational Health. He is a Medical Faculty member at the University of Hamburg and Director of the Institute for Occupational and Maritime Medicine, State Department of Health. He is a board certified physician in Occupational and Environmental Medicine, Internal Medicine, Allergology and Pulmonary Diseases.
Dr. Baur has been engaged in fine diagnostics of isocyanate asthma and hypersensitivity pneumonitis, respective antibody analyses and biomonitoring. His current activities refer to kinetics of isocyanate metabolism, biomarkers for isocyanate asthma and to hygiene issues associated with isocyanate exposure.
Dhimiter Bello ScD, MSc
Assistant Professor, School of Health & Environment, Department of Work Environment, University of Massachusetts, Lowell
Dr. Bello is an Assistant Professor of Occupational and Environmental Hygiene in the Department of Work Environment at University of Massachusetts Lowell. His background training was focused in organic analytical chemistry, exposure sciences, and environmental epidemiology.
Dr. Bello’s current research focuses broadly on exposure biology, an interdisciplinary approach which investigates quantitative and temporal relationships between exposures, tissue dosimetry, and disease. Exposure biology draws expertise from diverse fields such as exposure sciences, molecular biology, and mechanistic toxicology. One area of ongoing research is on developing new or improved analytical methodologies for quantitation of isocyanate skin and airborne exposures in workplace and consumer applications, and investigating relationships between the body burden and exposure pathways, especially through the skin.
David Bernstein MD, FACP
Professor of Clinical Medicine and Environmental Health; Co-director Allergy Fellowship Training Program, Division of Immunology, Allergy & Rheumatology, University of Cincinnati, College of Medicine
Senior Health Scientist, Directorate of Standards and Guidance, Occupational Safety & Health Administration
Janet Carter received a BS in Zoology from Miami University, MS in Molecular and Cell Biology from the University of Cincinnati and MPH from Emory University Rollin's School of Public Health. Janet is currently a Health Scientist in the Directorate of Standards and Guidance with the Occupational Safety and Health Administration (OSHA). Prior to working at OSHA, she worked for 15 years at Procter & Gamble, Inc. as a Respiratory Toxicologist and Study Director researching the mechanisms of particle-induced pulmonary inflammation/tumorigenesis and nanoparticle toxicity.
Janet has (co)authored over 35 publications and technical reports with more than 40 presentations and invited-talks at national and international conferences. In addition, she has participated on numerous scientific review panels with the National Academies Institute of Medicine, EPA, NIOSH, NSF and USDA. She is a member of the Society of Toxicology (SOT), American Public Health Association (APHA), former Vice-Chair of the International Life Science Institute/Health and Environmental Science Institutes (ILSI/HESI) Nanomaterials Safety Committee.
James J. Collins PhD
Director of Epidemiology, Dow Chemical Company
Dr. James Collins received his PhD in 1981 from the University of Illinois at Urbana-Champaign and is a Fellow in the American College of Epidemiology. He is currently the Director of Epidemiology at the Dow Chemical Company in Midland, Michigan. He is also an Adjunct Research Professor at the University of Pittsburgh, School of Public Health and at Saginaw Valley State University. Prior to joining Dow, he directed epidemiology programs at Solutia, Monsanto, Ford, and American Cyanamid and worked at Argonne National Laboratory. His major research interest is the impact of occupational and environmental exposures on health including exposures from dioxins, benzene, acrylonitrile, acrylamide, formaldehyde, and glutaraldehyde. He has published over 100 papers in these areas. He is currently an Officer in the American College of Epidemiology, Chairs the Scientific Advisory Panel for the National Urban Air Toxics Research Center, and is on the Editorial Boards for Environmental Health Perspectives, Journal of Environmental and Occupational Medicine and the Open Epidemiology Journal. He has also serves and has served on several science advisory committees including Houston’s Strategic Health Effects Research Panel, Oklahoma Center for Toxicology, Toxicology Excellence for Risk Assessment and several industry groups.
Corporate Medical Director, BASF Corporation
Dr. Conner has been the Corporate Medical Director for BASF Corporation, the North American subsidiary of BASF Group, since September 1994. He grew up in Burlington, North Carolina. His Bachelor’s degree is from The Johns Hopkins University. His Medical degree is from Duke University. He completed a straight Internal Medicine residency at the University of Alabama - Birmingham, and is board certified in Internal Medicine. He obtained additional training in Epidemiology at the University of North Carolina - Chapel Hill.
His primary professional interest is in linking workplace exposures to health outcome data. Consequently he has focused much of his attention on medical and Industrial Hygiene data systems. Since joining BASF he has added an interest in converting periodic, health examinations to more focused and scientifically based programs.
Research Chemist, Chemical Exposure and Monitoring Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention
Kathleen Ernst is a research chemist in the Division of Applied Research and Technology, Chemical Exposure and Monitoring Branch for the National Institute for Occupational Safety and Health (NIOSH). As project officer, her research focuses on isocyanate method development and exposure assessment. Her research includes development of NIOSH Method 5525, a total isocyanate method that utilizes 1-(9-anthracenylmethyl)piperazine (MAP) as the reagent, and continued research on development of methods that allow for the measurement of one analyte to quantify total NCO group in an air sample. She helped plan and implement an MDI exposure assessment study in the truck bed liner industry. She is a co-author of the NIOSH Alert, "Preventing Asthma and Death from MDI Exposure During Spray-on Truck Bed Liner and Related Applications," as well as peer reviewed journal articles. She is a contributor to a federal interagency workgroup that is focused on safety issues associated with spray polyurethane foam insulation.
Claude Emond MSc, PhD
Toxicologist, Researcher and Consultant, Clinical Adjunct Professor, Department of Environmental and Occupational Health, Université de Montréal
Dr. Claude Emond is a clinical adjunct professor in the Department of Environmental and Occupational Health at the University of Montreal, Quebec, Canada. He received a bachelor’s in Biochemistry from the Université du Québec à Montréal in 1987, a master’s degree in Environmental Health from the University of Montreal in 1997, and a Ph.D. in Public Health (Toxicology and Human Risk Assessment option) in 2001 from the University of Montreal, under the supervision of Dr Kannan Krishnan. From 2001 to 2004, Dr. Emond received grants from the National Research Council, a branch of the National Academy of Sciences (NAS), to perform postdoctoral studies for 2½ years at the U.S. Environmental Protection Agency (EPA) in North Carolina.
At EPA, Dr. Emond’s work focused on describing a developmental physiologically based pharmacokinetic (PBPK) model on dioxins. The research conducted by Dr. Emond’s team led to recognition from EPA administration and a presentation of EPA’s Scientific and Technological Achievement Award to the team. The team’s research is cited by NAS. While at EPA, his mentors were Dr. Michael DeVito and Dr. Linda S. Birnbaum. His research and consulting interests address problems in toxicology and focus on different chemicals, including polychlorinated biphenyls (PCBs), dioxins, flame retardants (polybrominated diphenyl ether [PBDE] and hexabromocyclododecane [HBCD]), bisphenol A, pyrethroid, and xenoestrogens. Dr Emond’s research interests also focus on the development and the improvement of mathematical PBPK models to address and reduce the uncertainty for toxicology risk assessment in human health.
David Fishwick MB, ChB, MRCP (UK), AFOM, MD
Co-director and Clinical Director, Centre for Workplace Health, Sheffield Thoracic Institute, University of Sheffield
David is curently a Consultant Respiratory Physician (or pulmonologist) with a major clinical and research interest in occupational lung disease and occupational asthma, holding the following roles; Consultant Respiratory Physician, STH Foundation NHS Trust, Co-Director of the Centre for Workplace Health (CWH), and Chief Medical Officer, Health and Safety Laboratory. In addition, he is an Honorary Professor of Occupational and Environmental Respiratory Medicine, University of Sheffield, awarded in 2010. David's research interests are focussed around the broad interface between the work environment and respiratory health. For example, he has active research interests in health surveillance for workers exposed to potentially harmful exposures at work including isocyanates and other low molecular weight chemicals, in addition to the diagnostic processes used to identify disease.
This work has led previously to the development of professional standards in this area, and the ability to influence policy. His teaching interests are related to the origins, identification and treatment of respiratory illness. At an undergraduate level, he coordinates early respiratory training, and at postgraduate level has been involved in many modalities of teaching delivery, including the development of an occupational health technician course with the University of Sheffield and a web hosted occupational asthma module with eBMJ.
George Charles Fonger
Technical Information Specialist/Senior Biologist, Office of Clinical Toxicology, Division of Specialized Information Services, National Library of Medicine, National Institutes of Health
George Charles Fonger has over 30 years experience in antineoplastic drug development, preclinical and clinical toxicology, environmental health, toxicology and the effects of chemical exposure to the environment. George was one of the original author’s of over 3,500 chemical substances found in the National Library of Medicine’s ( NLM) Hazardous Substances Data Bank (HSDB), which is maintained by NLM’s Division of Specialized Information Services. George serves as deputy project officer for the HSDB enhancement project and as a senior technical information specialist. George has published in a number of peer reviewed journals and an author of chapter in a book concerning information needs for those working with alternatives to animals in medicine and toxicology.
Armen Ghazarian, MPH
Cancer Research Training Award Fellow, Modifiable Risk Factors Branch, Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute
Mr. Ghazarian is a Cancer Research Training Award (CRTA) Fellow in the Epidemiology and Genomics Research Program’s (EGRP) Modifiable Risk Factors Branch (MRFB). He is currently working on projects involving gene and environment interactions, effects of indoor air pollution on cancer, and development of environmental questions for NCI’s Health Information National Trends Survey (HINTS). Additionally, Mr. Ghazarian is working in collaboration with EGRP’s Environment and Cancer Coordinating Committee on a manuscript analyzing how the definition of the environment and estimates of the proportion of cancer attributable to the environment have changed over time.
Julie E. Goodman PhD, DABT
Principal, Gradient Environmental Consultants
Julie E. Goodman is an epidemiologist and board-certified toxicologist specializing in human health risk assessment. She is a Principal at Gradient and an adjunct faculty member in the department of epidemiology at the Harvard School of Public Health.
Dr. Goodman focuses on assessing human health risks from chemicals in the environment and in consumer products. Her primary responsibilities include the analysis and interpretation of epidemiology and toxicology data, apparent disease clusters, and chemical exposures. Dr. Goodman has authored original research articles, review articles, and book chapters on a wide variety of topics related to epidemiology and toxicology, such as weight-of-evidence analyses of several chemicals, including toluene diisocyanate. She has presented scientific findings and analyses to community groups and regulatory and legislative bodies.
Terry Gordon PhD
Chair, Threshold Limit Values for Chemical Substances Committee, American Conference of Industrial Hygienists
Dr. Gordon is a Professor of Environmental Medicine at the NYU School of Medicine. Dr. Gordon's broad research interest is in inhalation toxicology and one focus of his research lab is the identification and understanding of the role of genetic host factors in the pathogenesis of the adverse pulmonary effects produced by inhaled environmental and occupational agents. Another major research focus is identifying PM components which contribute to the adverse effects of PM observed in vitro and in vivo. With a network of collaborators, test samples of PM have been collected throughout the U.S. at both urban and rural sites in both winter and summer.
Cynthia Graham PhD
Toxicology Principal, Huntsman LLC
Cynthia Graham is a Senior Toxicologist with Huntsman in The Woodlands, Texas. In her current role, she is the toxicology consultant for the Huntsman Polyurethanes and Advanced Materials businesses. She earned her Ph.D. and Masters of Science from the University of Pittsburgh, Graduate School of Public Health, Department of Environmental and Occupational Health and Toxicology, and a Bachelor of Science from Chatham University.
Dr. Graham's expertise is in the field of immunotoxicology -- evaluating the allergic dermal and respiratory responses to chemicals. Prior to joining the chemical industry, she worked for a clinical immunologist, Ming S. Lin, M.D., who treated patients with asthma and allergies. Dr. Graham has been involved in the investigation of dermal and respiratory responses to diisocyanates for over 18 years.
Dr. Graham is currently the Chair of the Americas Med-Tox Working Group of the International Isocyanate Institute (III). The III evaluates, reviews and contracts toxicological research on TDI and MDI to support the scientific strategy of the Institute with respect to health, safety and environmental issues relating to the manufacture, distribution and downstream use of MDI and TDI. Dr. Graham is a working member of the American Chemistry Council (ACC) Diisocyanates Panel, which engages on issues in United States and Canada and develops and disseminates information regarding the safe handling of TDI and MDI.
Carol Hetfield USEPA
Senior Advisor Economics, Exposure and Technology Division, Office of Pollution Prevention & Toxics, Environmental Protection Agency
Carol Hetfield is a senior advisor in the Economics, Exposure, and Technology Division (EETD) within the US Environmental Protection Agency's Office of Pollution Prevention & Toxics (OPPT). Carol is leading a federal workgroup on Spray Polyurethane Foam (SPF) with participation from other EPA programs and representatives from OSHA, NIOSH, ATSDR and CPSC. The federal workgroup is challenging the polyurethane industry to develop health and safety best practices while also looking at exposure assessment gaps. Carol is also an active participant in OPPT's MDI and TDI Action Plan workgroups.
Carol has a long-standing history working in OPPT's new chemicals program, including supporting the development of a "diisocyanates" chemical category; working with EPA's Design for the Environment (DfE) Program and the development of best practices for preventing exposures to diisocyanates in the automotive refinishing industry; and, leading the federal SPF workgroup in a workshop to begin to understand gaps in exposure assessment and understanding short-term and long-term research needs.
Vikas Kapil DO, MPH, FACOEM
Chief Medical Officer & Associate Director for Science, National Center for Environmental Health & Agency for Toxic Substances & Disease Registry, Centers for Disease Control and Prevention
Dr. Kapil is Chief Medical Officer and Associate Director for Science at the National Center for Environmental Health (NCEH) and the Agency for Toxic Substances and Disease Registry (ATSDR) of the Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia, USA. In this capacity, he oversees the environmental public health science and global environmental health activities at NCEH/ATSDR.
His research interests include environmental and occupational pulmonary diseases, environmental health problems in communities, environmental emergencies and environmental health problems and injury in low and middle income countries.
Brian Karlovich CIH, CSP
Product Safety & Regulatory Affairs, Bayer Material Science
Brian Karlovich is a Senior Product Safety Representative with the Product Safety & Regulatory Affairs group, Bayer MaterialScience LLC, Pittsburgh, Pennsylvania and has responsibility for the Bayer polyurethane and thermoplastic polyurethane product lines. He has served as the Manager of Industrial Hygiene Customer Services and as a Senior Industrial Hygienist within the same department prior to his current role. He holds a Bachelor of Science degree in Environmental Science from Allegheny College, and is a Certified Industrial Hygienist (CIH) and a Certified Safety Professional (CSP). Prior to working with Bayer, Mr. Karlovich spent 13 years working as an environmental, health, and safety consultant to industry, government, and academia. During that time, Mr. Karlovich worked on a variety of projects in roles ranging from staff scientist to project manager. Projects included, but were not limited to, soil and groundwater investigations and associated remediation systems installation and monitoring, Phase I
Environmental Site Assessments, asbestos and lead-based paint projects, indoor air quality investigations, and comprehensive industrial hygiene surveys.
Gerald L Kennedy Jr. DABT
Mr. Kennedy has been a toxicologist at DuPont’s Haskell Laboratory for Health and Environmental Sciences for 30 years. His primary interest at DuPont’s Haskell Laboratory has been in inhalation toxicology and how this information can be used for controlling exposure to chemicals in the workplace. Mr. Kennedy has been the Chair of DuPont Haskell Laboratory’s internal Acceptable Exposure Level Committee since its inception in 1977.
Before joining DuPont, he worked at Northwestern University’s Pathology Department, where he conducted descriptive toxicological studies for commercial clients and taught in the Biochemistry and Nutrition departments.
Mr. Kennedy joined ACGIH® in 1994 and has served on the ACGIH® Threshold Limit Values for Chemical Substances Committee from 1987 to the present. He is currently Co-Chair of the MISCO Subcommittee and a member of the Society of Toxicology serving on a number of administrative committees. He also consults with the National Library of Medicine as a toxicology reviewer for their Hazardous Substances Data Base activities.
Catherine Lemiere MD, MSc
Professor, Department of Medicine and Department of Environmental Health and Workplace Health, Université de Montréal
Dr. Lemiere is a Professor of Medicine and Environmental Health Medicine at the Université de Montréal (Montreal, Canada) and is also a Staff Chest Physician at Sacre-Cœur Hospital in Montreal. She is the head of the research respiratory group at Sacré-Coeur Hospital.
Dr. Lemiere’s research program is mainly focused on work-related asthma and more specifically, on the assessment of the airway inflammation present in this condition. She is currently supported by the Centre for Disease Control and Prevention (NIOSH-CDC) to characterize work-exacerbated asthma and occupational asthma. She has published over 120 peer review articles.
Gary Liss MD MS, FRCPC
Assistant Professor, Gage Occupational and Environmental Health Unit, Dalla Lana School of Public Health, University of Toronto; Consultant with Ontario Ministry of Labour
Dr. Liss is Assistant Professor, in the Gage Occupational and Environmental Health Unit, Dalla Lana School of Public Health, University of Toronto, and is affiliated with the Centre for Research Expertise in Occupational Disease (CREOD). He is a graduate of the University of Toronto Faculty of Medicine, and completed Occupational Medicine residency training at the University of Cincinnati, and obtained a Master of Science degree from that institution. Prior to returning to Canada, from 1981-84, Dr. Liss served as an Epidemic Intelligence Service (EIS) Officer with the National Institute for Occupational Safety and Health (NIOSH). He is certified in Occupational Medicine and Community Medicine by the Royal College of Physicians and Surgeons of Canada, and by the American Board of Preventive Medicine (Occupational Medicine).
Dr. Liss is also a Medical Consultant with the Ontario Ministry of Labour, Occupational Health and Safety Branch in Ontario. His research interests include diisocyanates, occupational disease, work-related asthma, epidemiology, occupational lung disease, surveillance, and latex allergy. He has been involved in investigations of the possible benefit of medical surveillance (secondary prevention) for occupational asthma (OA) by comparing outcomes among workers OA due to diisocyanates (for whom a regulation in Ontario requires period medical surveillance) with those having OA due to other causes (for whom medical surveillance is not required). He was also the lead author on what was perhaps the first cohort morbidity study examining rates of hospitalization among workers with OA (using record-linkage with the Ministry of Health); those with OA due to isocyanates were hospitalized less frequently than those with OA due to other causes, possibly due to earlier recognition and less severe asthma. In collaboration with Health Canada, Dr. Liss has recently investigated the quality of the health information on MSDSs for diisocyanate-containing products.
Andrew Maier PhD, CIH, DABT
Director, Toxicology Excellence for Risk Assessmment (TERA)
Dr. Maier has extensive professional work experience in the areas of environmental health, industrial hygiene, and toxicology. He is the Director of the non-profit organization Toxicology Excellence for Risk Assessment (TERA) where he leads efforts in developing occupational and environmental exposure guidelines. He completed his PhD in toxicology from the University of Cincinnati, where he currently holds a position as an Adjunct Associate Professor of Environmental Health. He earned a M.S. in Industrial Health from the University of Michigan and has field IH experience in the chemical industry. Dr. Maier is Board certified in both toxicology and comprehensive industrial hygiene practice. Recently his research efforts have focused on methods and approaches for using biological exposure and effect markers to reduce uncertainties in risk assessment and methodologies for deriving occupational exposure limits. He is the immediate past-chair of the American Industrial Hygiene Association Workplace Environmental Exposure Levels (WEEL) Committee and the Vice-President of the Society of Toxicology Occupational and Public Health Specialty Section. He currently is serving as a Toxicology Fellow with the National Institute for Occupational Safety and Health where he is developing methods for OEL derivation.
Senior Principal Scientist, Bayer Material Science
Karen Mattson is a senior principal scientist at Bayer MaterialScience LLC in Pittsburgh who has held various positions in industrial analytical organizations for over 20 years and is currently managing the company’s environmental analytics group which includes its industrial hygiene and environmental testing laboratories.
Bayer’s industrial hygiene laboratory provides analytical testing for airborne and surface contaminants in the workplace,specializing in isocyanate analysis of personal exposure monitoring samples from Bayer’s production plants and those of our customers. The laboratory has been the contract laboratory for the American Chemistry Council (ACC)/National Institutes of Safety and Health TDI epidemiology study for the past six years and is involved in the analysis of samples for several different research projects for the ACC Center for the Polyurethanes Industry.
Dr. Mattson is a member of the International Isocyanates Institute (III) serving on both the Americas Analytical Working Group and the Analytical Advisory Group. She is III's US representative to the ISO work group responsible for isocyanate methods for workplace atmospheres (ISO TC 146/SC2/WG4).
Aubrey Miller MD, MPH
Senior Medical Advisor, NIH/National Institute of Environmental Health Sciences
In May, 2010, Aubrey Miller, M.D., M.P.H. joined the NIEHS team to serve as Senior Medical Advisor and NIEHS liaison to the U.S. Department of Health and Human Services (HHS). Miller’s office is located on the NIH Campus in Bethesda where he oversees a small staff of NIEHS employees who are readily available to meet with NIH and HHS representatives, federal partners, members of Congress, and other stakeholders to discuss how environmental factors influence human health and disease. Miller is coordinating many federal efforts, including playing a major role in the NIEHS and HHS response to the Gulf of Mexico oil spill.
A medical epidemiologist and a Captain in the U.S. Public Health Service, Miller has longstanding experience, publications, and contributions to a wide range of occupational and environmental health issues and policies. Miller previously served as the Chief Medical Officer for the U.S. Food and Drug Administration (FDA), Office of Counterterrorism and Emerging Threats. Previously he worked as a Senior Medical Officer and Regional Toxicologist for the U.S. Environmental Protection Agency (EPA) and for the U.S. Department of Health and Human Services (HHS) Office of the Secretary in Denver, providing leadership, expertise, and coordination for multi-agency emergency responses, such as the Libby Montana asbestos situation, the anthrax attacks in Washington, DC, and Hurricane Katrina. He also conducted over 30 field investigations while working for several years as a Medical Officer for the Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH).
Asish Mohapatra MSc, Mhpil, EMC, Risk Cert.
Regional Health Risk Assessment and Toxicology Specialist, Contaminated Sites, Environmental Health Program, Regions and Programs Branch, Health Canada
Asish Mohapatra is a Health Risk Assessment and Toxicology Specialist working for Health Canada (Prairies Region) Contaminated Sites group. He has 15 years of experience in the public and private sectors in the areas of life sciences, environmental public health sciences, chemical, biological and computational toxicology, human health risk assessment and management and remediation. pecifically, in the areas of chemical, biological and radiological toxicology and health risk assessments, he has worked as a expert reviewer of contaminated sites health risk assessment projects including issues pertaining to indoor and outdoor environmental quality.
He has conducted uncertainty analysis, quantitative risk assessment modelling, and toxicological evaluations of chemical and biological and radiological stressors. He has been evaluating existing and emerging predictive tools and advanced computational technologies (e.g., semantic web technologies and data fusion tools) to effectively use them to analyze, disseminate, and share toxicological and health risk assessment data of complex chemical clusters from disparate sources under public health toxicology and risk assessment frameworks. Recent works included technical reference book publications in the areas of toxicology, toxicoinformatics and global chemical management and collaborative work with several global agencies and multi-stakeholder groups and initiatives in the area of dose response techniques, predictive toxicology applications and system biology database and knowledge integration.
Benoit Nemery MD, PhD
Professor of Toxicology & Occupational Medicine, Chair, Department of Public Health, Universiteit Leuven
Ben Nemery is holder of degrees in medicine (Leuven, 1977), occupational medicine (Louvain, 1980) and toxicology (MSc, University of Surrey, 1982; and PhD, Council for National Academic Awards, UK, 1986). He has been affiliated with the Medical Faculty of the KU Leuven since 1987, heading the research unit of Lung Toxicology, which is a joint venture between the departments of Pneumology and of Occupational, Environmental and Insurance Medicine. He was promoted to full professor in 1998, and was chair of the KU Leuven Department of Public Health (2005-2011).
His research involves experimental as well as clinical-epidemiological studies in the mechanisms of lung disease caused by occupational and environmental agents. He is co-author of over 200 publications in international biomedical journals and has contributions in more than 40 books. He holds a weekly outpatient clinic for occupational pulmonary disorders. He teaches toxicology and occupational medicine, mainly at postgraduate level.
A. Martin Nicholas PhD
Head, Public Awareness, Surveillance and National Compliance Coordination Chef, National Office of the Workplace Hazardous Materials Information System, Health Canada
Leena A Nylander-French PhD, CIH
Professor of Occupational and Environmental Health, University of North Carolina at Chapel Hill, Department of Environmental Sciences and Engineering, Gillings School of Global Public Health
Leena Nylander-French is professor of occupational and environmental health at the University of North Carolina Gillings School of Public Health at Chapel Hill. Dr. Nylander-French received the MS degree from the University of Kuopio, Finland and the PhD degree from the Royal Institute of Technology, Stockholm, Sweden, both in Environmental and Occupational Hygiene. She is a Certified Industrial Hygienist and a member of the National Research Council of the National Academies’ Committee on Acute Exposure Guideline Levels. She is also a member of the American Conference of Governmental Industrial Hygienists' Biological Exposure Indices Committee.
Her research and teaching program is focused on understanding the consequences of human exposure to toxic substances. Her laboratory has pioneered approaches to quantitatively measure both inhalation and skin exposures to toxicants, including isocyanates. Her group is actively engaged in the measurement of occupational and environmental exposures, biological monitoring, and developing sophisticated mathematical, statistical and toxicokinetic exposure-modeling tools in an effort to standardize and improve exposure and risk assessment. She has extensive experience in conducting occupational and environmental exposure assessment studies both in Europe and in the US.
Lyn Penniman RN, MPH
Director, Office of Physical Hazards and Others, Occupational Safety & Health Administration, US Department of Labor
Lyn Penniman is currently the Director of the Office of Physical Hazards in the Directorate of Standards and Guidance at the Occupational Safety and Health Administration (OSHA), in Washington DC. She has participated in the development of numerous regulatory and non-regulatory occupational risk management activities in her career at OSHA. Her interests in occupational asthma and health care came together in the development of OSHA’s Best Practices for the Safe Use of Glutaraldehyde. She is currently managing the team developing a Request for Information on Chemical Management, to be published in the last quarter of 2012.
Ken Rosenman MD, MSU
Chief, Division of Occupational and Environmental Medicine, Professor of Medicine, Division of Occupational and Environmental Medicine, Michigan State University
Dr. Rosenman is a Professor of Medicine and Chief of the Division of Occupational and Environmental Medicine at Michigan State University. He received the MSU distinguished faculty award in 2010. Dr. Rosenman is Board-Certified in Internal Medicine and in Occupational and Environmental Medicine. He received his medical degree from New York Medical College in 1975. He is a Fellow of the American College of Epidemiology and the American College of Preventive Medicine.
Under the direction of Dr. Rosenman, the occupational and environmental health team at Michigan State University works closely with the Michigan OSHA program and the Michigan Department of Community Health to administer Michigan’s occupational injury and illness surveillance program. He has an active research program in occupational and environmental disease with particular interest in the methodology for tracking occupational conditions and the etiology of pulmonary disease. He has published approximately 160 articles on occupational and environmental disease.
Editor in Chief, CCC Newsletter, NIOSH Office of Health Communication & Global Collaboration
Ronald Shiotsuka PhD, DABT
Head of Toxicology BMS-NAFTA, Bayer Material Science
Debra Silverman ScD, ScM
Chief, Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute
Dr. Silverman is chief of the Occupational and Environmental Epidemiology Branch within the Division of Cancer Epidemiology and Genetics, NCI. She received a Sc.D. in epidemiology from the Harvard School of Public Health and a Sc.M. in biostatistics from The Johns Hopkins Bloomberg School of Hygiene and Public Health. She joined the NCI as a biostatistician in 1972, and has served as a cancer epidemiologist since 1983. Dr. Silverman has received numerous awards, including PHS Special Recognition Award for research on environmental determinants of bladder and other cancers; the American Occupational Medical Association Merit in Authorship Award for her paper on a job/exposure linkage system; the NCI Special Act Award in recognition of her work on the Diesel Exhaust in Miners Study; the NIH Merit Award for her contributions to pancreatic cancer research; the PHS Lucy Minnigerode Award; and the DCEG Exemplary Service and Investigator Award.
Gunnar Skarping PhD
Professor, Department of Analytical Chemistry, Work Environment Chemistry Division, Stockholm University
Professor Skarping is head of the division of Work Environment Chemistry, Stockholm University. Professor Skarping has been consultant to manufacturer polyurethane made implants, companies that manufacture mass spectrometers regarding chemical ionisation and software for mass spectrometry, consultant to Sigma Aldrich, Division of Supelco regarding air sampling technology for isocyanates, several major petroleum companies regarding air sampling and biomonitoring among workers and international isocyanate institute (III) for air monitoring methodology.
Professor Skarping is convener of ISO TC146/SC2/WG4 and is a member of the scientific committee of IOHA. Professor Skarping has publicised more than 100 publications and two patents. Main areas of scientific work includes: methodology for air monitoring of isocyanates and amines in gas and size selective particle sampling, development of new dry samplers.
Mark W. Spence MS, CIH
Scientific Director, International Isocyanate Institute
A native of upstate New York, Mark Spence received a BS degree in chemistry from Clarkson University and an MS in chemistry from Michigan State University. He worked in various Environment, Health and Safety and Regulatory Affairs roles at the Dow Chemical Company for over 30 years. Mark is a Certified Industrial Hygienist and was involved in polyurethane industry EH&S issues for over 20 years while at Dow.
S ince 2010, Mark has worked for the International Isocyanate Institute (III). He has served as the Scientific Director of the III since January 2011.
Eileen Storey, MD, MPH
Chief, Surveillance Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention; Professor Emeritus, Department of Medicine, School of Medicine, University of Connecticut; Adjunct Professor of Community Medicine, School of Medicine, West Virginia University
Eileen Storey, MD, MPH is Chief of the Surveillance Branch of the Division of Respiratory Disease Studies (DRDS) in NIOSH/CDC. The Branch summarizes information relating to the incidence, prevalence, and mortality of occupational respiratory diseases; describes patterns of specific diseases within occupations and industries; and develops methods to monitor specific working populations at risk for respiratory disease. She is the project officer for research which NIOSH is conducting in collaboration with the American Chemistry Council Diisocyanates Panel: “Model Medical Surveillance Program for Occupational Asthma and to Characterize the Incidence of Occupational Asthma Associated with Toluene Diisocyanate Exposure in the Production Environment.” Participating sites will complete five years of medical and environmental monitoring in July, 2012.
Susan M Tarlo FRCPC, MBBS
Professor, Dept. of Medicine and Dalla Lana School of Public Health, University of Toronto; Staff Physician, Respiratory Division, University Health Network and St. Michael's Hospital
Dr Susan M Tarlo finished medical school in London, England at Westminster Medical School and undertook further training in England until coming to Canada when she undertook specialty training in allergy and clinical immunology and then pulmonary medicine at Queen’s and McMaster Universities. She then started her staff physician appointment at University of Toronto.
She is a Professor in the Department of Medicine and has an academic cross-appointment in the Dalla Lana School of Public Health at the University of Toronto. She is a pulmonary physician and head of the Occupational Lung Clinic at the Toronto Western Hospital site of the University Health Network, and has a research appointment at the Gage Occupational and Environmental Health Unit in Toronto and the Centre for Research Excellence in Occupational Disease at St Michael’s Hospital.
Her research interests are mainly in work-related asthma and occupational allergy. A focus has been on identifying changes in prevalence of diisocyanate-related asthma, and associations with preventive measures.
PU IH Technical & EHS Issue Manager, Huntsman Corporation
Erik Vangronsveld is a Senior Industrial Hygienist with Huntsman in Everberg, Belgium. In his current role he is the Industrial Hygienist consultant for the Huntsman Polyurethanes business.
Erik’s expertise is in the field of industrial hygiene air sampling and analysis of isocyanates and he has been involved in investigating polyurethane (PU) industry workplaces for over 20 years.
Erik is currently the Chair of the Global Analytical Advisory Group of the International Isocyanate Institute (III) and in this role a member of the III Scientific Committee. The III evaluates, reviews and contracts scientific research, including industrial hygiene sampling and analytical, on TDI and MDI to support the scientific strategy of the Institute with respect to improving the understanding of workplace health, safety and environmental (EHS) conditions where TDI and MDI are used. Part of this research includes investigating the accuracy, reliability and applicability of existing or new isocyanate sampling and analytical techniques or develop those in support of the safe manufacture, distribution and downstream use of MDI and TDI.
Gail Weinmann MD
Deputy Director, Division of Lung Diseases, National Heart, Lung, and Blood Institute
Marc White PhD
Clinical Assistant Professor, Department of Family Practice, University of British Columbia;Executive Director, Canadian Institute for the Relief of Pain and Disability
Dr. Marc White is the co-founder and executive director of the Canadian Institute for the Relief of Pain and Disability which was established in 1985 in collaboration with (the Late) Dr. John McM. Mennell (Physical Medicine Consultant to the US Armed Forces). Dr. White is a Clinical Assistant Professor with the Department of Family Practice at the University of British Columbia and a principal investigator affiliated with AUTO21, Networks of Centres of Excellence.
Dr. White is the lead investigator for the Health and Work Productivity Web-Portal, an academic community partnership dedicated to translating best evidence on disability prevention and employee health. He has organized over 20 international and national conferences held in Canada, United States, United Kingdom and Europe. He has organized 5 international strategic meetings. He is an invited scientific reviewer for several journals including Canadian Family Physician, The Journal of Rheumatology, Injury Prevention (BMJ), and Journal of Occupational and Environmental Medicine. Dr. White is a board member of the BC Collaborative for Disability Prevention and a board member for the Canadian Pain Coalition.
Lynn Wilder PhD, CIH Associate
Director for Science (Acting), Division of Community Health Investigations (Proposed), Agency for Toxic Substances and Diseases Registry
Dr. Wilder is currently working as the Associate Director for Science in the Division of Community Health Investigation (Proposed), ATSDR. She has more than 26 years of experience in environmental and biological sampling and exposure studies. Prior to becoming the associate director, Lynn worked in ATSDR’s Health Studies program where her major responsibilities included negotiating scientific epidemiologic approaches and methods with stakeholders including ATSDR health professionals, the U.S. Environmental Protection Agency (EPA), state and local health departments, community groups, academia, and industry; manage and lead health investigations and epidemiologic studies for communities exposed to environmental contaminants. Lynn also worked in ATSDR’s Exposure Investigation and Consultation Branch, as an ATSDR Regional Representative (Region 3), as an EPA On-Scene Coordinator, and as a government contractor.
Her most recent projects include the NC toluene diisocyanate community exposure study and two construction and demolition debris (C&D) landfill health investigation. She was a co-investigator for the NCEH FEMA trailer formaldehyde mitigation technology assessment and the ATSDR lead for the Federal response to the Chinese drywall investigations.
Adam V. Wisnewski PhD
Senior Research Scientist, Occupational Medicine, Yale School of Medicine
Dr. Wisnewski's research focuses on normal and pathogenic responses to occupational and environmental exposure, with an emphasis on isocyanates, a leading cause of occupational asthma. He uses a multi-pronged approach to study fundamental mechanisms of exposure-induced human disease, through bench studies with human tissue samples, clinical studies of “at risk” populations, and in vivo studies in mice to answer questions that cannot be ethically or practically addressed clinically. Specific highlights of his research investigations include (a) structural elucidation of TDI, and other isocyanates, reactivity with human proteins, using pioneering in vitro (vapor phase exposure) approaches, (b) seminal work defining the role of skin in the development of systemic immune hypersensitivity to isocyanate exposure, as well as (c) bioinformatic analyses of isocyanate exposure effects on airway epithelial cells, especially influences on thiol-redox homeostasis and oxidative stress. New immunoassays developed have been used to aid industrial hygiene efforts by the US Air Force (Hill AFB). A particular strength of his research throughout his career has been my focus on trying to understand critical scientific unknowns through direct studies on affected human populations, ranging from parasite/viral-infected patients to chemically exposed workers. His combined experience in clinical research and laboratory skills have prepared me to lead the investiagtion propopsed herein.